Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4‐arylamino‐ 3‐nitrocoumarin derivatives |
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| Authors: | Vidoslav Deki? Niko Radulovi? Rastko Vuki?evi? Biljana Deki? Danielle Skropeta Radosav Pali? |
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| Institution: | 1. Department of Chemistry, Faculty of Science and Mathematics, University of Pri?tina, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia;2. Department of Chemistry, Faculty of Science and Mathematics, University of Ni?, Vi?egradska 33, 18000 Ni?, Serbia;3. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi?a 12, 34000 Kragujevac, Serbia;4. School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia |
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| Abstract: | Herein, we describe the synthesis and complete assignment of the 1H and 13C NMR chemical shifts of a series of antimicrobial 4‐arylamino‐3‐nitrocoumarin derivatives based on a combination of 1H and 13C NMR, 1H‐1H‐COSY, NOESY, HSQC and HMBC experiments. Conformational effects upon the chemical shifts of the coumarin moiety arising from the anisotropy of the aryl side group are briefly discussed. This study provides the first complete and fully assigned NMR data for this important group of antimicrobial compounds and bridges the gap existing in the literature with regard to NMR structural data for 4‐arylamino‐3‐nitrocoumarins. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | 1H NMR 13C NMR 2D NMR 4‐arylamino‐3‐nitrocoumarins synthesis structure elucidation molecular conformation |
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