ESI‐MS studies of palladium (II) complexes with 1‐(p‐toluenesulfonyl)cytosine/cytosinato ligands |
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Authors: | Renata Kobetić Dubravka Gembarovski Aleksandar Višnjevac Biserka Žinić Vesna Gabelica‐Marković |
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Affiliation: | 1. Division of Organic Chemistry and Biochemistry, Ruder Bo?kovi? Institute, Bijeni?ka cesta 54, 10 000 Zagreb, Croatia;2. GlaxoSmithKline, Research Centre Zagreb, Prilaz baruna Filipovi?a 29, 10 000 Zagreb, Croatia;3. Division of Physical Chemistry, Ruder Bo?kovi? Institute, Bijeni?ka cesta 54, 10 000 Zagreb, Croatia |
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Abstract: | The mononuclear complex Pd(1‐TosC‐N3)2Cl2 (2) containing 1‐(p‐toluenesulfonyl)cytosine (1) as a ligand, as well as dinuclear complexes Pd2(1‐TosC?‐N3,N4)4 (3) and Pd2(1‐TosC?‐N3,N4)2DMSO2Cl2 (4) containing the ligand anion (1‐TosC?), was mass analyzed by electrospray ionization ion trap MS/MS and high resolution MS. Complexes 3 and 4 were obtained by recrystallization of 2 from DMF and DMSO, respectively. The behavior of complex 2 in different solutions was monitored by electrospray ionization mass spectrometry (ESI‐MS). Under the applied ESI‐MS conditions, complex 2 in methanol reorganized itself dominantly as new complex 3 and the solvent did not coordinate the formed species. In H2O/DMSO, CH3CN/DMSO and CH3OH/DMSO solutions, complex 2 formed several new species with solvent molecules involved in their structure, e.g. complex 4 was formed as the major product. The newly formed species were also examined by LC‐MS‐DAD, confirming the solvent induced reorganization and the solution instability of complex 2. Copyright © 2009 John Wiley & Sons, Ltd. |
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Keywords: | palladium (II) complexes 1‐(p‐toluenesulfonyl)cytosine dimethyl sulfoxide methanol ESI‐MS |
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