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Synthesis of picolinohydrazides and their evaluation as ligands in the zinc-catalyzed hydrosilylation of ketones |
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| Authors: | Vita Surzhko Thierry Roisnel Barbara Le Grel Philippe Le Grel Claudia Lalli Gilles Argouarch |
| Institution: | 1. Université de Rennes 1, UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe CORINT, UFR des Sciences Biologiques et Pharmaceutiques, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France;2. Université de Rennes 1, UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Centre de Diffractométrie X, 263 Avenue du Général Leclerc, 35042 Rennes Cedex, France |
| Abstract: | A set of picolinohydrazides was prepared by reaction between hydrazines and either 2-picolinic acid or ethyl pyridine-2-carboxylate, and characterized. These molecules were evaluated as ligands in the zinc-catalyzed hydrosilylation of ketones. Thus, several aromatic and aliphatic ketones were successfully reduced by diethoxymethylsilane as the hydride source in the presence of a catalytic system made of diethylzinc combined in situ to the picolinohydrazides described herein. |
| Keywords: | Hydrosilylation Zinc Hydrazides Ketones |
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