Synthesis of 2,3-dihydropyrroles by photo rearrangement of Hantzsch 1,4-dihydropyridines with high diastereoselectivity |
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| Authors: | Qidi Zhong Qiangwen Fan Hong Yan |
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| Institution: | College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, PR China |
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| Abstract: | The Hantzsch 1,4-dihydropyridines were found to be transforming to the 2,3-dihydropyrroles by photo rearrangement with air under irradiation of LED light (410 nm) with high diastereoselectivity (dr > 20:1). This reaction includes tandem photo oxidation/rearrangement. The 2,3-dihydropyrroles were obtained in moderate yields with successfully one-pot process starting from aldehydes, ammonium acetate and ethyl acetoacetate. |
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| Keywords: | 2 3-Dihydropyrroles Photo rearrangement One-pot Diastereoselectivity |
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