| A new variant of Knorr's pyrrole synthesis |
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| 作者姓名： | ZHANG Yan JIANG Yun-Zhen LIANG Xiao-TianInstitute of Materia Medico Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China |
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| 作者单位： | ZHANG，Yan JIANG，Yun-Zhen LIANG，Xiao-TianInstitute of Materia Medico，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100050，China |
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| 摘 要： | The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates.The influence of p-substituents of aniline and the feasibility with other ketones were studied.N-aryl-indole-3-carboxylate (17) was synthesized successfully with this method.The unique character of p-methoxy-aniline in this reaction was discussed.
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A new variant of Knorr's pyrrole synthesis |
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| ZHANG,Yan JIANG,Yun-Zhen LIANG,Xiao-TianInstitute of Materia Medico,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China.A new variant of Knorr''''s pyrrole synthesis[J].Chinese Journal of Chemistry,1997,15(4):371-378. |
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| Authors: | ZHANG Yan JIANG Yun-Zhen LIANG Xiao-TianInstitute of Materia Medico Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China |
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| Institution: | ZHANG,Yan JIANG,Yun-Zhen LIANG,Xiao-TianInstitute of Materia Medico,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China |
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| Abstract: | The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates.The influence of p-substituents of aniline and the feasibility with other ketones were studied.N-aryl-indole-3-carboxylate (17) was synthesized successfully with this method.The unique character of p-methoxy-aniline in this reaction was discussed. |
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| Keywords: | Pyrrole synthesis ethyl 3-bromopyruvate anilines ketones |
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