Chemie des 2-Aminospiro[indan-1,3′-pyrrolidin]-Systems

The chemistry of the 2-aminospiroindan-1,3′-pyrrolidine]system 2-Aminospirindan-1,3′-pyrrolidines] 1 are easily synthesized from the α-hydroxyiminoketones 6 and 19 (Schemes 2 and 3, and 6 respectively). Removal of the N-acetyl group in the intermediate 8 of the trans series induces transposition to the 3a-aminomethyl-indano2,1-b]pyrrolidine system. The configurations of all compounds have been determined by ¹H-NMR. spectroscopy.