| Comparative studies on the mechanism of uridine phosphorolysis |
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| 引用本文： | ZHAO,Shan-Rong CHEN,Kai-Xian JIANG,Hua-Liang WANG,Qin-Mi JI,Ru-YunShanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China. Comparative studies on the mechanism of uridine phosphorolysis[J]. 中国化学, 1997, 15(1): 84-89. DOI: 10.1002/cjoc.19970150115 |
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| 作者姓名： | ZHAO Shan-Rong CHEN Kai-Xian JIANG Hua-Liang WANG Qin-Mi JI Ru-YunShanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 200031 China |
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| 作者单位： | ZHAO，Shan-Rong CHEN，Kai-Xian JIANG，Hua-Liang WANG，Qin-Mi JI，Ru-YunShanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031，China |
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| 摘 要： | We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid-catalyzed SN2 mechanism. The proposed reaction pathway is consistent with many experimental results.
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Comparative studies on the mechanism of uridine phosphorolysis |
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| ZHAO,Shan-Rong CHEN,Kai-Xian JIANG,Hua-Liang WANG,Qin-Mi JI,Ru-Yun. Comparative studies on the mechanism of uridine phosphorolysis[J]. Chinese Journal of Chemistry, 1997, 15(1): 84-89. DOI: 10.1002/cjoc.19970150115 |
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| Authors: | ZHAO Shan-Rong CHEN Kai-Xian JIANG Hua-Liang WANG Qin-Mi JI Ru-Yun |
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| Affiliation: | ZHAO,Shan-Rong CHEN,Kai-Xian JIANG,Hua-Liang WANG,Qin-Mi JI,Ru-YunShanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China |
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| Abstract: | We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid-catalyzed SN2 mechanism. The proposed reaction pathway is consistent with many experimental results. |
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| Keywords: | Transition state uridine phosphorolysis reaction mechanism nucleophilic substitution intrinsic reaction coordinate |
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