Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes |
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| Authors: | Mizuta Satoshi Shibata Norio Ogawa Shinichi Fujimoto Hiroyuki Nakamura Shuichi Toru Takeshi |
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| Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. |
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| Abstract: | The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(O iPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfully applied this methodology to the difluoromethylation of aldehydes using Me3SiCF2SePh, Me3SiCF2P(O)OEt2 and Me3SiCF2SPh. |
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