The reaction of propane sultone with cuanosine,adenosine, and related compounds

Propane sultone (3-hydroxypropanesulfonic acid-γ-lactone) which is a monofunctional directacting alkylating carcinogen, has been shown to react irreversibly with DNA from various sources in vitro. It reacts with guanosine in DMSO to yield the N-7 alkyl nucleoside, while reaction with 2′-deoxyguanosine yields the corresponding N-7 alkyl purine. Evidence for the structure of these products and of one formed when adenosine and propane sultone react is presented.