Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride |
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| Authors: | Heshmatollah Alinezhad Mahmood Tajbakhsh Fatemeh Salehian Kazem Fazli |
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| Affiliation: | 1. Faculty of Chemistry , Mazandaran University , Babolsar, Iran heshmat@umz.ac.ir;3. Faculty of Chemistry , Mazandaran University , Babolsar, Iran |
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| Abstract: | An efficient, general procedure for reductive methylation of primary and secondary amines with 37% formaldehyde using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent gave the corresponding tertiary amines in excellent yields. The reaction was carried out in tetrahydrofuran under neutral conditions at 0–10 °C. |
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| Keywords: | Amine formaldehyde reductive methylation ZBHNMP |
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