Choline Chloride/Urea Ionic Liquid Catalyzed a Convenient One-Pot Synthesis of Indole-3-propanamide Derivatives |
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Authors: | Eranna Siddalingamurthy Thamatakallu O. Shrungesh Kumar |
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Affiliation: | Department of Postgraduate Studies and Research in Chemistry, School of Chemical Science , Kuvempu University , Shankaraghatta , Karnataka , India |
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Abstract: | A sequential three-component reaction of aromatic aldehydes with Meldrum's acid and N-methyl indole in the presence of choline chloride/urea ionic liquid as green catalyst has been described. In this one-pot multicomponent reaction, a series of indole-3-propanamide derivatives were synthesized with good to excellent yields. This methodology shows several advantages including fast reaction, easy isolation, operational simplicity that make it a useful and attractive option for the library generation of indole-3-propanamides (5a–l) for drug discovery. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resources: Full experimental and spectral details.] |
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Keywords: | Choline chloride/urea indole-3-propanamides Meldrum's acid multicomponent reaction |
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