Reduction of the Δ13-15-Keto Grouping of Prostaglandin Intermediates |
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Authors: | Donald H Picker Niels H Andersen Elizabeth M K Leovey |
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Institution: | Dept. of Chemistry , University of Washington , Seattle, WA, 98195 |
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Abstract: | In an attempt to gain further information on a stereo-structural model for activity of prostaglandins,2 we undertook the synthesis of a number of new analogues.3 In particular, 17,17-dimethyl-F2α was chosen as a good test of the “hairpin” conformation because the two 17-methyl groups would prevent side chain alignment in the particular sense of the “hairpin” model.4 |
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