Ecofriendly Solventless Synthesis and Reduction Reaction of Some Triazole Compounds and Evaluation of Their Antimicrobial Activity |
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| Authors: | Musa Özil Emre Menteşe Şengül Alpay Karaoğlu Bahittin Kahveci |
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| Affiliation: | 1. Department of Chemistry , Faculty of Sciences and Arts, Recep Tayyip Erdo?an University , Rize , Turkey musa.ozil@rize.edu.tr;3. Department of Chemistry , Faculty of Sciences and Arts, Recep Tayyip Erdo?an University , Rize , Turkey;4. Department of Biology , Faculty of Sciences and Arts, Recep Tayyip Erdo?an University , Rize , Turkey;5. Department of Nutrition and Dietetics, Faculty of Health Sciences , Karadeniz Technical University , Trabzon , Turkey |
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| Abstract: | A number of triazole-3-one compounds have been synthesized, and reduction of the carbonyl group in the molecule has been carried out to give a corresponding hydroxyl group that possesses asymmetric carbon atom in good yields and short reaction times. It is ecofriendly because it is produced by straightforward microwave irradiation in the absence of solvent. All newly synthesized compounds were also screened for their antimicrobial activities. The antimicrobial activity study revealed that 2d, 2i, 3c, and 3g–j showed good activity against a variety of microorganisms. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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| Keywords: | Antimicrobial activity green chemistry microwave-assisted synthesis solvent-free 1,2,4-triazole-3-one |
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