Prins Cyclization of Styrenes or Acetophenone Catalyzed by DBSA in Water |
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| Authors: | Juan Zhang Lin Hua Feifei Li Xuefen Wu Shengzhi Tian |
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| Institution: | 1. Henan University of Traditional Chinese Medicine , Zhengzhou , China;2. Institute of Chemistry, Henan Academy of Sciences , Zhengzhou , China |
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| Abstract: | Dodecylbenzenesulfonic acid (DBSA) was proved to be an efficient catalyst for Prins cyclization of styrenes and formaldehyde or acetaldehyde in water. A tandem dehydration/Prins cyclization reaction using a tertiary alcohol and formaldehyde as substrates proceeded very well by using DBSA as catalyst. Acetophenone, which is less reactive compared with styrene, can also react with formaldehyde when catalyzed by DBSA in water to afford 1,3-dioxan-5-ylphenylmethanone in good yield. |
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| Keywords: | DBSA 1 3-dioxane organic reactions in water Prins cyclization |
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