A facile approach to 6-amino-2H-pyrano[2,3-g]isoquinolin-2-ones via a sequential Sonogashira coupling of 6-cyanoumbelliferone triflate and annulations with amines |
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Authors: | Alla V Lipeeva Makhmut M Shakirov |
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Institution: | Medicinal Chemistry Department, Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation |
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Abstract: | Palladium-catalyzed synthesis of 2H-pyrano2,3-g]isoquinolinones have been described from easily accessible precursor 6-cyanoumbelliferone triflate via sequential of Sonogashira coupling and the following annulations with several primary alkylamines under basic conditions The so obtained 6-propargylamino-2H-pyrano2,3-g]isoquinolinones were involved in the CuAAC reaction with 2-azidobenzoic acid for obtaining 2H-pyrano2,3-g]isoquinoline-benzoic acid hybrid compounds containing a 1,2,3-triazole linker. |
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Keywords: | Alkynes Click chemistry coumarin heterocyclization Sonogashira reaction |
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