Synthesis of Novel 1,2,3-Triazole-dihydro[3,2-c]chromenones as Acetylcholinesterase Inhibitors |
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| Authors: | Mina Saeedi Shirin Ansari Mohammad Mahdavi Reyhaneh Sabourian Tahmineh Akbarzadeh Alireza Foroumadi |
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| Institution: | 1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | A novel series of 1,2,3-triazole-dihydro3,2-c]chromenone derivatives were synthesized through an efficient three-step reaction starting from 4-hydroxybenzaldehyde. All the newly synthesized compounds were characterized by infrared and NMR spectroscopy as well as elemental analysis and evaluated for their acetylcholinesterase inhibitory activity. |
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| Keywords: | Acetylcholinesterase heterocycles 1 2 3-triazole-dihydro[3 2-c]chromenones |
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