KG-60-Piperazine as a New Heterogeneous Catalyst for Gewald Three-Component Reaction |
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| Authors: | Esmail Rezaei-Seresht Reza Tayebee Mohammad Yasemi |
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| Institution: | 1. Department of Chemistry, Faculty of Sciences , Hakim Sabzevari University , Sabzevar , Iran rezaei_seresht@yahoo.com;3. Department of Chemistry, Faculty of Sciences , Hakim Sabzevari University , Sabzevar , Iran |
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| Abstract: | Piperazine supported on amorphous silica (KG-60-piperazine) as a basic catalyst acts in the Gewald three-component reaction of some aldehydes and ketones with malononitrile as well as ethyl cyanoacetate. The catalyst shows general utility with a variety of starting carbonyl compounds. Moreover, the catalyst can be reused for four additional cycles without significant loss of the activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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| Keywords: | 2-Aminothiophenes Gewald reaction heterogeneous catalysis multicomponent reaction |
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