Straightforward Synthesis of 1,2-Amino Phosphate Diesters and Application to the Synthesis of Novel 1,2-Amino Ether Diesters |
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| Authors: | Brahim Ould Elemine Mohamed Rached Ennigrou |
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| Affiliation: | Faculty of Sciences, Department of Chemistry , Laboratoire de Synthèse Organique par voie Organométallique , Tunis , Tunisia |
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| Abstract: | A variety of 1,2-amino alcohol diesters 1 reacted smoothly with diethyl chlorophosphate under basic conditions to afford the corresponding 1,2-amino phosphate diesters 2 in excellent yields. These compounds served as useful precursors for subsequent nucleophilic attack by alcohols in an SN2 fashion to provide 1,2-amino ether diesters 3. |
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| Keywords: | 1,2-Amino alcohol diesters 1,2-amino ether diesters 1,2-amino phosphate diesters diethyl chlorophosphate |
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