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Efficient Synthesis of New Peptidyl Chloromethyl Ketones for the Application of Proteinase K Inhibitors |
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| Authors: | Anilkumar R Kore Muthian Shanmugasundaram |
| Institution: | 1. Life Technologies Inc., Bioorganic Chemistry Division , Austin , Texas , USA anil.kore@lifetech.com;3. Life Technologies Inc., Bioorganic Chemistry Division , Austin , Texas , USA |
| Abstract: | The synthesis of a new series of peptidyl chloromethyl ketones such as MeOSuc-Ala-Ala-Pro-Ile-CH2Cl (AAPI) and MeOSuc-Ala-Ala-Ala-Pro-Ile-CH2Cl (AAAPI) is described. |
| Keywords: | Chloromethyl ketones isoleucine proteinase K inhibitor serine protease |