Facile Access to Mono-Cinchona Alkaloid-Derived Ligands |
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| Authors: | Hai-Bo Wang Ping-An Wang Quan-Jun Wang Peng-Juan Nan Lin-Lin Jing |
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| Institution: | Department of Chemistry , School of Pharmacy, Fourth Military Medical University , Xi'an, China |
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| Abstract: | Two facile accesses to mono-cinchona alkaloid-derived ligands, by conventional heating conditions and solvent-free microwave irradiation, are described. 1,4-Dichlorophthalazine (PHAL) or 3,6-dichloropyridazine (PYDZ) reacted with quinine (QN), cinchonine (CN), or cinchonidine (CND) by using CaH2 as acid-bonding reagent in DMF at 90–100°C to provide mono-cinchona alkaloid-derived ligands 2a–f (87–95%) in 1.5 h. However, the coupling reactions were performed under solvent-free microwave conditions to yield 2a–f (64–89%) within 15 min. |
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| Keywords: | CaH2 1 4-dichlorophthalazine 3 6-dichloropyridazine microwave irradiation mono-cinchona alkaloid-derived ligands |
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