One-Pot and Solvent-Free Synthesis of 1,4-Dihydropyridines and 3,4-Dihydropyrimidine-2-ones Using New Synthetic Recyclable Catalyst via Biginelli and Hantzsch Reactions |
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Authors: | Abbas Shockravi Mahmood Kamali Negar Sharifi Mahdieh Nategholeslam Somayeh Pahlavan Moghanlo |
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Affiliation: | 1. Faculty of Chemistry , Kharazmi University (formerly Tarbiat Moallem University) , Tehran , Iran abbas_shockravi@yahoo.co.uk;3. Faculty of Chemistry , Kharazmi University (formerly Tarbiat Moallem University) , Tehran , Iran |
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Abstract: | Pyridine dicarboxylic acid guanidine–cobalt complex (PDAG-Co) (3) catalyzes one-pot, three-component coupling of aldehydes, β-dicarbonyl compounds, and ammonium acetate to afford the corresponding 1,4-dihydropyridines (1,4-DHPs) via Hantzsch reaction. 3,4-Dihydropyrimidine-2-ones (3,4-DHPMs) and their sulfur analogs are also synthesized under the same conditions via Biginelli condensation protocol. The catalyst is reusable at least five times, highly efficient, easily prepared, and used under mild reaction conditions. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view free supplemental file. |
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Keywords: | Biginelli cobalt-catalyst 3,4-dihydropyrimidine-2-ones 1,4-dihydropyridines Hantzsch |
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