Efficient Synthesis of 3-Substituted 1,2,4-Triazolo[4,3-a]pyridine by [Bis(Trifluroacetoxy)iodo]benzene-Catalyzed Oxidative Intramolecular Cyclization of Heterocyclic Hydrazones |
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| Authors: | Vikas S Padalkar Vikas S Patil Kiran R Phatangare Prashant G Umape |
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| Institution: | Institute of Chemical Technology , Matunga , Mumbai , India |
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| Abstract: | A series of 1,2,4-triazolopyridines have been prepared by oxidative intramolecular cyclization of heterocyclic hydrazones with bis(trifluroacetoxy)iodo]benzene. General applicability of this simple transformation was confirmed by synthesis of 1,2,4-triazolo4,3-a]pyridine. The advantages of this protocol are the nontoxicity of catalyst and shorter reaction time to obtain good preparative yield.  Additional information ACKNOWLEDGMENT The author is thankful to Indian Institute of Technology Mumbai, for providing the 1H NMR facility. |
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| Keywords: | [Bis(trifluroacetoxy)iodo]benzene hydrazones oxidation 1 2 4-triazole |
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