Air Oxidation of N-Cyclopropylanilines |
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Authors: | Anthony Blackburn Daniel M Bowles Hui Kim |
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Institution: | 1. Pfizer Global Research and Development, Michigan Laboratories , Ann Arbor , Michigan , USA;2. Pfizer Global Research and Development, Groton Laboratories , Groton , Connecticut , USA |
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Abstract: | Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. While potential mechanisms have been previously proposed, simple aerobic oxidation to β-hydroxy-propionamides in the absence of a radical promoter has not been previously reported. |
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Keywords: | Air oxidation cyclopropyl aniline fragmentation rearrangement |
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