Efficient and Selective Demethylation of Heteroaryl Methyl Ethers in the Presence of Aryl Methyl Ethers |
| |
| Authors: | Ajay Soni Akhilesh Dutt Viswajanani Sattigeri Ian A Cliffe |
| |
| Institution: | 1. Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories , Gurgaon , Haryana , India ajay.soni@ranbaxy.com;3. Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories , Gurgaon , Haryana , India |
| |
| Abstract: | A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl methyl ethers.  Additional information ACKNOWLEDGMENTS We thank the Analytical Chemistry Department of New Drug Discovery Research, Ranbaxy Research Laboratories, for spectral and chromatographic data. We also thank Dr. Jitendra Sattigeri for helpful suggestions and comments. |
| |
| Keywords: | Demethylation lithium chloride 2-methoxypyrdidine p-toluenesulfonic acid pyridine-2-one |
|
|
