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Triflic Acid–Catalyzed Michael Reactions of Indole and Pyrrole Compounds with α,β‐Unsaturated Ketones in Water |
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| Authors: | Hai‐Bo Zhang Li Liu Yu‐Liang Liu Yong‐Jun Chen Jun Wang |
| Institution: | Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences , Beijing, China |
| Abstract: | The Michael reactions of indole and pyrrole compounds to α,β‐unsaturated ketones catalyzed by triflic acid (HOTf, 0.1–1 mol%) were performed in water to give alkylated indoles (3a–m) and dialkylsubstituted pyrroles (6a–b) in good to excellent yields. |
| Keywords: | catalytic and aqueous Michael reaction indole pyrrole triflic acid α β‐unsaturated ketone |