Efficient Approach for the Synthesis of Novel Functionalized Isoxazolines from Limonene |
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| Authors: | Amal Feddouli Mustapha Ait Ali Aïssa Hasnaoui Abdelkhalek Riahi |
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| Institution: | 1. Department of Chemistry, Faculty of Science‐Semlalia , Marrakech, Morocco;2. Mixed Unity of Research ?Selective Reactions and Applications? NCSR, University of Rheims Champagne‐Ardenne , Rheims, France |
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| Abstract: | New functionalized isoxazolines were effeciently and easily prepared from limonene. The procedure involves a peri‐ and regioselective 1,3‐dipolar cycloaddition of nitrile oxides on the monoterpene external double bond, followed by a highly chemoselective RuCl3‐NaIO4 oxidative cleavage of the internal one. All the newly prepared isoxazolyl‐ketoacids were fully characterized from their spectroscopic data. |
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| Keywords: | 1 3‐dipolar cycloaddition isoxazolyl‐ketoacids limonene nitrile oxides oxidative cleavage ruthenium |
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