Synthesis of Phosphonopeptide Derivatives |
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| Authors: | M. Hariharan S. Chaberek A. E. Martell |
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| Affiliation: | 1. Department of Chemistry , Texas A&2. M University , College Station, Texas, 77843 |
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| Abstract: | In 1959, Horiguchi and Kandatsu1 first isolated 2-aminomethylphos-phonic acid from ciliate protozoa. Since then the compound has been found in numerous other organisms2 and recently it has been found in human brain3, liver, heart and skeletal muscles4, and in red blood cell membrane. These findings establish the biological importance of the carbon-phosphorus bond in nature. Quin2 suggested that the naturally occurring aminophosphonic acids are bound to proteins and peptides. |
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