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Synthesis of Unprotected Carboxy Indazoles via Pd-Catalyzed Carbonylation |
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| Authors: | Philip Wainwright Remedios Perni Clare Vickers Steven B. Coffey Leanne Buzon Kenneth DiRico |
| Affiliation: | 1. Peakdale Molecular Ltd., Chapel-en-le-Frith , High Peak , United Kingdom phil.wainwright@peakdale.co.uk;3. Peakdale Molecular Ltd., Chapel-en-le-Frith , High Peak , United Kingdom;4. Pfizer Worldwide Research and Development , Groton , Connecticut , USA |
| Abstract: | The first published synthesis of unprotected carboxy indazoles from the corresponding bromoindazoles is described. This is achieved via Pd(II)-catalyzed carbonylation and is demonstrated to work on a variety of indazoles. |
| Keywords: | Carbonylation carboxylic acids halides indazoles palladium |