One-Step Protection-Free Synthesis of 3-Aryl-5-hydroxyalkyl-1,2,4-oxadiazoles as Building Blocks |
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Authors: | Ricardo A W Neves Filho Diana C B da Silva-Alves Janaína V dos Anjos |
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Institution: | Departamento de Química Fundamental , Universidade Federal de Pernambuco , Recife , Brazil |
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Abstract: | A simple and straightforward synthesis of 3-aryl-5-hydroxyalkyl-1,2,4-oxadiazoles is described. The reaction among arylamidoximes, ethyl glycolate or ethyl lactate, and potassium carbonate in refluxing toluene afforded the desired 1,2,4-oxadiazoles in moderate to good yields. The synthesis has been accomplished in a single step, avoiding protection–deprotection protocols. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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Keywords: | Cyclodehydration 1 2 4-oxadiazoles thermal reaction |
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