Simple and Efficient Synthesis of 5-Substituted-3-phenyl-2-thioxoimidazolidin-4-one Derivatives from S-Amino Acids and Phenylisothiocyanate in Et3N/DMF-H2O |
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| Authors: | Asha D Jangale Yogesh B Wagh Yogesh A Tayade |
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| Institution: | School of Chemical Sciences, North Maharashtra University, Jalgaon, India |
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| Abstract: | A concise approach for the transformation of various S-amino acids into the 5-alkyl-3-phenyl-2-thioxoimidazolidin-4-one heterocycles using phenylisothiocyanate is described. Phenylthiohydantoins of amino acid were synthesized at room temperature in Et3N/DMF-H2O with easy workup and excellent yields. |
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| Keywords: | Amino acids cyclization phenylisothiocyanate 2-thiohydantoin |
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