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Study on the Synthesis and Bioactivity of Novel Mahkoside A Derivatives |
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| Authors: | Yan‐Bing Zhang Pi‐Yong Zhang Gui‐Fu Dai |
| Affiliation: | Department of Chemistry , New Drug Research and Development Center, Zhengzhou University , Zhengzhou, China |
| Abstract: | Abstract A series of novel Mahkoside A derivatives was synthesized, and their in vitro cytotoxic activities were evaluated against the human cancer cell line Ec‐9706. A Preliminary structure–activity relationship study showed compounds 7 and 8 have obvious cytotoxic activities (IC50: 30.0 and 12.5 µg · mL?1, respectively). |
| Keywords: | benzophenone Koenigs–Knorr reaction Mahkoside A 2,3,6‐tri‐O‐acetyl‐4‐chloro‐4‐deoxy‐β‐ smallcaps smallerCapital" >D‐galactoside |