Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones |
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| Authors: | Hamid Reza Shaterian Ali Reza Oveisi Moones Honarmand |
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| Affiliation: | 1. Department of Chemistry, Faculty of Sciences , University of Sistan and Baluchestan , Zahedan, Iran hrshaterian@hamoon.usb.ac.ir;3. Department of Chemistry, Faculty of Sciences , University of Sistan and Baluchestan , Zahedan, Iran |
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| Abstract: | An efficient, inexpensive, and heterogeneous catalyst, [Al(H2PO4)3], was applied in a three-component, one-pot cyclocondensation reaction of isatoic anhydride with primary amines (or ammonium salts) and aldehydes to afford the corresponding quinazolinone derivatives in excellent yields. Reactions occurred under thermal solvent-free conditions. It was found that this solid acidic catalyst could be easily recovered and reused for at least three cycles without any loss of activity. |
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| Keywords: | [Al(H2PO4)3] 3-(2′benzothiazolo)-2,3-dihydroqunazoline-4(1H)-ones isatoic anhydride solvent-free |
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