Simple Synthesis of Pyrroles Under Solvent-Free Conditions |
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| Authors: | Surya K De |
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| Institution: | 1. Burnham Institute for Medical Research , La Jolla, California, USA skd125@yahoo.com |
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| Abstract: | Paal–Knorr condensation of 2,5-hexadione with primary amines in the presence of a catalytic amount of praseodymium(III) trifluoromethanesulfonate under solvent-free conditions has been accomplished with an excellent yield. This method is a very easy, rapid, and high-yielding reaction for the synthesis of N-substituted pyrrole derivatives. |
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| Keywords: | Paal–Knorr reaction praseodymium tiflate pyrroles solvent-free conditions |
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