A Convenient One-Step Synthesis of 2-Hydroxy-1,3,5-Benzenetricarbaldehyde |
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| Authors: | Andrew A Anderson Thomas Goetzen Scott A Shackelford Stella Tsank |
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| Institution: | Agouron Pharmaceuticals, Inc., Alanex Division , 3550 General Atomics Court, San Diego, California, 92115 |
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| Abstract: | The hexamethylenetetramine/trifluoroacetic acid system was demonstrated to be capable of introducing three aldehyde groups into the phenol molecule. Facile, one-step procedures were developed for the preparation of hitherto difficult to synthesize 2-hydroxy-1,3,5-benzenetricarbaldehyde starting from either phenol or 4-hydroxybenzaldehyde. New pKa measurements showed 2-hydroxy-1,3,5-benzenetricarbaldehyde to be an acid stronger than previously reported. |
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| Keywords: | 4‐Ar‐2‐bromopyridine 2 2‐Bipyridine 2‐Bromo‐4‐iodopyridine Stille‐coupling |
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