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Facile and Simple Synthesis of Ring C Aromatic Diterpenes: Synthesis of (+)-13-Hydroxypodocarpa-8,11,13-triene and (+)-7-Deoxynimbidiol |
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| Authors: | José E. Villamizar Carlos Gamez Antonio Alcalá Franklin Salazar Eleonora Tropper Ana Angarita |
| Affiliation: | 1. Centro de Química, Instituto Venezolano de Investigaciones Científicas (I.V.I.C.) , Caracas , Venezuela jvillami@ivic.gob.ve;3. Centro de Química, Instituto Venezolano de Investigaciones Científicas (I.V.I.C.) , Caracas , Venezuela |
| Abstract: | Alpha alkylation of the nitro group of nitrochromenes was performed by trapping of the nitronate salt generated by NaBH4 reduction with a Michael acceptor. The adducts were used for the synthesis of spiro-[N-hydroxy]-lactams. |
| Keywords: | Abietane diterpenes 7-deoxynimbidiol nimbidiol podocarpane diterpenes synthesis |