Oxone‐Mediated Oxidative 3‐Arylthio Substitution of Indoles |
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| Authors: | Guaili Wu Jing Wu Jialiang Wu |
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| Institution: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, Gansu, 730000, China |
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| Abstract: | Oxone‐mediated oxidative 3‐arylthio substitution of indoles with benzenethiols in methanol has been succeeded, giving 3‐arylthioindoles. Indoles bearing a 2‐methyl group particularly exhibited higher activities toward 3‐arylthio substitutions. 3‐(2′‐Pyridylthio)indoles used as selective COX‐2 inhibitors were prepared in good to excellent yields. |
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| Keywords: | 3‐Arylthioindole benzenethiol 2‐mercaptopyridine oxone selective COX‐2 inhibitor |
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