Simple,Catalyst-Free,One-Pot Procedure for the Synthesis of 2-Amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one Derivatives |
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Authors: | Meng-Jian Yao Zhi Guan |
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Affiliation: | School of Chemistry and Chemical Engineering , Southwest University , Chongqing , P. R. China |
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Abstract: | A one-pot, three-component reaction of 4-hydroxyquinolin-2(1H)-one, malononitrile, and various aldehydes for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives is reported. The reaction is performed without any catalysts in a mixed solvent of water and ethanol to give products in good yields. The present method provided a clean, simple, and economical alternative for the synthesis of potential biologically active pyranoquinoline derivatives. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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Keywords: | Catalyst-free multicomponent reaction pyranoquinoline derivative synthesis |
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