Catalyst-free synthesis of 3-substituted-3-hydroxy-2-oxindoles by reaction of isatin and cyclic enaminone in water |
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| Authors: | Keshri Nath Tiwari Snehal Rajendra Thakar Vaneet Kumar S M Prabhakaran |
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| Institution: | 1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), ITI Compound, Raebareli 229010, Indiakeshri.tiwari@niperraebareli.edu.in;3. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), ITI Compound, Raebareli 229010, India |
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| Abstract: | An easy protocol for the synthesis of enaminone attached 3-substituted-3-hydroxy-2-oxindoles has been demonstrated by reaction of isatin and cyclic enaminone in water. The developed catalyst-free reaction has the advantage of being atom-economical, eco-friendly, and benign reaction conditions. The broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive and useful. |
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| Keywords: | Dimedone enaminone isatin oxindole water |
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