Microwave-assisted Cannizzaro reaction—Optimisation of reaction conditions |
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| Authors: | Łukasz Janczewski Małgorzata Walczak Justyna Frączyk Zbigniew J Kamiński |
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| Institution: | Institute of Organic Chemistry, Lodz University of Technology, Lodz, Poland |
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| Abstract: | The microwave-assisted Cannizzaro reaction was studied in order to develop fully reproducible synthetic protocols for transformation of aldehydes to carboxylic acid and alcohols. Optimised were the following process parameters: power, temperature, and time. Aromatic, heteroaromatic and aliphatic aldehydes were used in the studies. It was found that furfural, thiophene-2-carbaldehyde, pyridinecarboxaldehyde and aromatic aldehydes react under mild conditions, while 1-methyl-pyrrole-2-carboxaldehyde derivatives and aliphatic aldehydes require more drastic reaction conditions and a longer exposure time to microwave radiation. |
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| Keywords: | Aromatic and aliphatic aldehydes crossed Cannizzaro reaction microwave irradiation optimal conditions reproducibility synthetic protocols |
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