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Expedient Strategy for the Synthesis of 5-Acylethynylpyrrole-2-carbaldehydes |
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| Authors: | Denis N. Tomilin Lyubov N. Sobenina Marina V. Markova Maxim D. Gotsko Igor A. Ushakov Vladimir I. Smirnov |
| Affiliation: | A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russian Federation |
| Abstract: | 5-Acylethynylpyrrole-2-carbaldehydes have been synthesized from the protected pyrrole-2-carbaldehydes by their transition-metal-free topochemical mechanoactivated ethynylation with acylbromoacetylenes in a solid Al2O3 medium (room temperature, 6 h, 41–54% yields). |
| Keywords: | Acylbromoacetylenes Al2O3 ethynylation 5-ethynylpyrrole-2-carbaldehydes pyrrole-2-carbaldehydes |