Perchloric Acid-Catalyzed Synthesis of 9-Aryl Xanthenes-9H-3,6-diol and 1,3,6,8-Tetraol in Water |
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Authors: | Nikhil Vidyasagar Rabindra Nanda Rajesh Mangal |
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Affiliation: | Padmashree Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research , Pimpri , Pune , India |
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Abstract: | Efficient syntheses of xanthenes have been described using a catalytic amount of perchloric acid in water. The high temperature and lengthy reaction time normally required for formation of xanthenes derivatives are not necessary when using a catalytic amount of perchloric acid. The method is relatively inexpensive, easily available, nonvolatile, nonexplosive, and thermally robust to catalyze the reaction at 80 °C by simple heating with good to excellent yields. The advantages of the reaction involve simple reaction protocol, simple workup, and improved synthesis in the presence of perchloric acid as catalyst. |
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Keywords: | Perchloric acid phloroglucinol resorcinol water xanthenes |
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