Facile One-Pot Conversion of Aldehydes into Amides |
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| Authors: | Samuel T. Chill |
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| Affiliation: | Department of Chemistry , University of Tennessee at Chattanooga , Chattanooga, Tennessee, USA |
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| Abstract: | A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100°C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67–95%) and purity (>95%). |
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| Keywords: | Aldehyde amide hydrogen peroxide nitrile tandem reaction |
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