One-Pot Green Synthesis of Novel Polysubstituted 1,2-Dihydronaphtho[2,1-b]furans |
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Authors: | Mahdieh Sadeghpour Abolfazl Olyaei Jamshid Lotfiyan Fatemeh Rajabi |
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Affiliation: | 1. Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan, Iranm.sadeghpour@tiau.ac.ir;3. Department of Chemistry, Payame Noor University (PNU), Tehran, Iran |
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Abstract: | A simple and highly efficient one-pot protocol for the synthesis of novel polysubstituted 1,2-dihydronaphtho[2,1-b] furans has been developed by three-component coupling reaction of 2-aminopyridines, naphthols, and glyoxal in the presence of guanidinium chloride as a polyfunctional organocatalyst under solvent-free conditions. The protocol avoids the use of expensive catalysts, toxic solvents, and chromatographic separation and provides a wide range of novel dihydronaphthofurans in good to excellent yields. |
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Keywords: | 1,2-Dihydronaphtho[2,1-b]furans 2-aminopyridines glyoxal naphthol |
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