New Achievements in the Field of Intramolecular Phenolic Coupling Reactions,Using Hypervalent (III) Iodine Reagent: Synthesis of Galanthamine |
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| Authors: | Dikran Krikorian Velichko Tarpanov Stoyan Parushev Pepa Mechkarova |
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| Affiliation: | Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences , 1113, Sofia, Bulgaria E-mail: dik@orgchm.bas.bg |
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| Abstract: | Our investigations on the oxidative possibilities of the hypervalent iodine(III) reagent established that phenyliodine(III)bis(trifluoroacclate) (PIFA) can provide one-pot contiguous coupling-cyclization reaction giving a product with narwedine skeleton, when used in a phenolic coupling reaction of p'-bromonorbelladine derivatives. A suitably selected precursor gave up to 60% yield of the coupled product. |
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