Allylic Hydroxylation Through Acid Catalysed Epoxy Ring Opening of Betulinic Acid Derivatives |
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| Authors: | Swapan Pramanick Suparna Mandal Sailen Jha |
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| Affiliation: | 1. Medicinal Chemistry Division , Indian Institute of Chemical Biology , Kolkata, India;2. Department of Chemistry , Jadavpur University , Kolkata, India |
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| Abstract: | Acid catalysed epoxy ring opening of several lupane type triterpenoids leads to unusual allylic hydroxylation. The reaction involves the formation of epoxide by m‐chloroperbenzoic acid followed by the treatment of mineral acid. The simple methodology finds utility to introduce a hydroxyl function at the allylic position in these triterpenoids, which is otherwise quite difficult. |
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| Keywords: | Betulinic acid derivatives allylic hydroxylation |
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