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Efficient selective oxidation of alcohols to aldehydes catalyzed by a morpholinone nitroxide |
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| Authors: | Zhenhua Dong Pengwei Gao Yongmei Xiao |
| Institution: | 1. College of Chemistry and Chemical Engineering, Academician Workstation for Natural Medicinal Chemistry of Henan Province, Henan University of Technology, Zhengzhou, PR Chinahautdong@foxmail.com;3. College of Chemistry and Chemical Engineering, Academician Workstation for Natural Medicinal Chemistry of Henan Province, Henan University of Technology, Zhengzhou, PR China |
| Abstract: | Efficient chemoselective oxidation of primary alcohols to the corresponding aldehydes is described. The transformation is promoted by a catalytic morpholinone nitroxide radical catalyst which can be easily synthesized. A broad range of substrates including aromatic and aliphatic primary alcohols are converted with excellent yields under mild conditions. The control experiments reveal that the morpholinone nitroxide can be used as a selective oxidant for primary alcohols in the presence of secondary alcohols. |
| Keywords: | Aaldehyde nitroxide oxidation primary alcohol TEMPO analog |