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Improved Process for the Preparation of Tamsulosin Hydrochloride |
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| Authors: | A. Veera Reddy S. Udaya Bhaskara Rao G. Lakshmi Narasimha P. K. Dubey |
| Affiliation: | 1. Research and Development Laboratories, Suven Life Sciences Ltd. , Hyderabad, India reddyvenis@rediffmail.com;3. Research and Development Laboratories, Suven Life Sciences Ltd. , Hyderabad, India;4. Department of Chemistry , College of Engineering, J. N. T. University , Hyderabad, India |
| Abstract: | Ellman's sulfinamide reagent is used in asymmetric synthesis of Tamsulosin hydrochloride. The enantiomeric ratio achieved is 87:13. The crystallization of the same with dibenzoyl tartarate afforded the product 2 with >99.5% ee. |
| Keywords: | Dibenzoyl tartarate hydrogenation t-butyl sulfinamide (Ellman's sulfinamide) |