Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents |
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| Authors: | Hayam H Sayed Eman M H Morsy Eman R Kotb |
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| Institution: | 1. Photochemistry Department , National Research Centre , Dokki, Cairo, Egypt Hayamsayed@yahoo.com;3. Photochemistry Department , National Research Centre , Dokki, Cairo, Egypt |
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| Abstract: | A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1′-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4–7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity. |
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| Keywords: | Antimicrobial activities bis-thiazolopyrimidine pyrazolothiazole thiazolopyridine thiazolopyrimidine |
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