Convenient Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Acid Derivatives via Isocyanide-Based,Three-Component Reactions |
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| Authors: | Ildikó Schuster László Lázár |
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| Affiliation: | Institute of Pharmaceutical Chemistry, University of Szeged , Szeged, Hungary |
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| Abstract: | The three-component reactions of 3,4-dihydroisoquinolines, isocyanides, and benzyl chloroformate furnished 2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Hydrogenolysis or selective hydrolysis of the benzyloxycarbonyl group provided 1,2,3,4-tetrahydroisoquinoline-1-carboxamides, further hydrolysis of which resulted in the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids. |
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| Keywords: | roman" >α-Amino acids isocyanides isoquinolines multicomponent reactions |
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