A New Convenient Approach to Preparation of 5 or 6 or 7-Nitro-1,2,3,4-Tetrahydrisoquinolines and 2-Alkylsulfonyl-5 or 6 or 7-Nitro-1,2,3,4-Tetrahydroisoquinolines |
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| Authors: | Chongzhao Ran Guoping Wang Taizhi Wu Meihua Xie |
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| Institution: | Shanghai Institute of Pharmaceutical Industry , Shanghai, 200437, P. R. China |
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| Abstract: | N-alkylsulfonyl-p or m or o -nitrophenylethylamines were treated with (HCHO)n in 60% H2SO4/HOAc to give N-alkylsulfonyl-5 or 6 or 7-nitro-1,2,3,4-tetrahydroisoquinolines, then hydrolyzed with 40% HBr to give 5 or 6 or 7-nitro-1,2,3,4-tetrahydroisoquinolines |
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